Is an effective antimicrobial and antiprotozoal agent broad spectrum. The drug shows high dianabol review activity against protozoa.Trichomonas vaginalis, Giardia intestinalis, Entamoeba histolytica, Lamblia intestinalis, Balantidium coli, Blastocystis hominis, Helicobacter pylori;
against obligate anaerobes (sporo- and asporogenous): Bacteroides spp (B fragilis, B. ovatus, B. distasonis, B. theraiotaomicron, B. vulgatus.), Fusobacterium spp, Clostridium spp, Peptostreptococcus spp, Peptococcus spp…. ., Eubacterium sensitive strains.
Metronidazole is active against facultative anaerobic bacteria: Gardnerellu vaginalis.
After intravaginal application of metronidazole absorbed slightly. The active ingredient is metabolized in the liver. Provided by 40-70% (20% in unchanged form) via the kidneys. Bioavailability in intravaginal application of metronidazole is 19%.
Local treatment of Trichomonas vaginitis and nonspecific.
Hypersensitivity to metronidazole or other nitroimidazole derivatives; blood disease, leukopenia (including history); incoordination, organic CNS (including epilepsy); hepatic insufficiency (in the case of the appointment of large doses), pregnancy, breastfeeding.
Dosing and Administration
– Trichomonas vaginitis:
1 suppository per day for 10 days.
– Nonspecific vaginitis:
1 suppository 2 times a day for 7 days.
Pre-releasing suppository from the contour package with scissors (to cut the film along the contour of a suppository) introduce it deep into the vagina.
When local use, you may experience the following side effects:
– Itching, burning, pain and irritation in the vagina; thick, white, mucous discharge from the vagina, odorless or with a faint odor, frequent urination; after discontinuation of the drug – may develop vaginal candidiasis;
– Burning dianabol review sensation or irritation of the penis in the sexual partner; on the part of the gastrointestinal tract: nausea, change in taste, metallic taste in the mouth, dry mouth, decreased appetite, cramping abdominal pain, nausea, vomiting, constipation or diarrhea;
– Allergic reactions: rash, itching, skin rash;
– Leukopenia or leukocytosis.
In rare cases, there may be urine staining in red-brown color due to the presence of water-soluble pigment produced in the metabolism of metronidazole.
Interaction with other drugs
Compatible with antibiotics and sulfonamides. In the treatment of metronidazole should avoid alcohol intake (similar to disulfiram causes alcohol intolerance). Not to be combined with disulfiram, metronidazole, because the interaction of these drugs is possible depression of consciousness, development psizicheskih disorders.
With simultaneous use of warfarin and other indirect anticoagulants metronidazole increases their action, which leads to an increase in prothrombin time. Do not combine with non-depolarizing muscle relaxants (vecuronium).
Under the influence of barbiturates may reduce the effect of metronidazole as accelerating its inactivation in the liver.
Cimetidine inhibits metabilizm metronidazole, which may lead to an increase in its concentration in the serum and an increased risk of adverse reactions.
When concomitantly with drugs lithium may increase the concentration of the latter in plasma.
metronidazole treatment should not last more than 10 days and recur more often than 2-3 times a year.
In the treatment of Trichomonas vaginitis in women and Trichomonas urethritis in men advised to refrain from sexual intercourse. When vaginitis caused vaginalis of Trichomonas , to the simultaneous treatment of sexual partner metronidazole drug for oral administration.
In the case of the drug in conjunction with metronidazole for oral administration, especially in repeated courses necessary to monitor patterns of peripheral blood (risk of leukopenia).
In the period of treatment is contraindicated reception of ethanol (development disulfirampodobnoy reaction: abdominal cramping, nausea, vomiting, headache, sudden rush of blood to the face.
It is dianabol review necessary to pay attention to patients, especially drivers of vehicles and persons that control other machines, to the possibility of dizziness associated with taking the drug.