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Hepatoprotective activity due metadoksina membrane stabilizing effect and is based on the ability restores ratio of saturated and unsaturated free fatty acids. As a result, this increases the resistance of hepatocytes to the action of lipid peroxidation, which occurs when exposed to various toxic agents. Detoxification effect metadoksina due to activation of liver enzymes involved in the metabolism of ethanol – alcohol dehydrogenase and acetaldehyde dehydrogenase, which accelerates the elimination of ethanol and acetaldehyde dianabol steroid from the body and thus reduces their toxic effects.
Metadoksin prevents the accumulation of triglycerides in the hepatocytes, and prevents the formation of fibronectin and collagen, which significantly slows down the process of formation of cirrhosis of the liver.
The drug reduces the psychic and somatic symptoms of hangover, reduces the relief of withdrawal symptoms.
Metadoksin activates cholinergic and GABAergic neurotransmitter system, improves the function of thinking and short-term memory, prevents the emergence of motor excitation, which is caused by ethanol.
Metadoksin has a non-specific anti-depressant and anxiolytic effects, reduces the craving for alcohol.

Pharmacokinetics
The drug is rapidly absorbed from the gastrointestinal tract and has a high bioavailability (60-80%). Communication with plasma proteins – 50%. It is metabolized in the liver to active metabolites – pyridine and pyrrolidone carboxylate. The half-life (T½) ingestion or parenteral administration is 40 – 60 minutes. 45 – 50% of the drug excreted in the urine within 24 hours, 35 – 50% of the drug excreted in the feces within 96 hours.

Indications

  • acute alcohol intoxication
  • alcohol withdrawal syndrome
  • Saint Martin’s dianabol steroid evil
  • complex therapy of liver diseases, especially alcoholic etiology

 

Contraindications

  • hypersensitivity to any component of the drug
  • lactation
  • during pregnancy

 

Precautions
Use with caution in Parkinson’s disease when levodopa is used at the same time, because metadoksin reduces the effectiveness of drugs.
The vials of solution for injection contains sodium metabisulfite. This substance can cause in susceptible people, especially those suffering from bronchial asthma, allergic reactions, or increase in asthma attacks.

Use during pregnancy and lactation Use of the drug during pregnancy and lactation is not recommended.

Dosing and dose Acute alcohol intoxication: 300-600 mg (10.5 ml) was intramuscularly or 300 – 900 mg of (5-15 ml) intravenously, depending on the degree of intoxication. When administered intravenously, the required dose of the drug is diluted in 500 ml of isotonic sodium chloride solution or 5% dextrose (glucose), and introducing drip for 1.5 hours. Combined therapy of liver disease and chronic alcoholism: 1 tablet 2 times a day (1000 mg) for 15-30 minutes before meals, the dose can be increased to three tablets (1500 mg) per day. The course of treatment should be at least 90 days. Alcohol withdrawal syndrome: 900 mg (15 mL) as an intravenous infusion (supra.) Once a day for 3-7 days depending on the condition of the patient.

 

Side effects:
Allergic reactions. Patients with asthma may develop bronchospasm (using formulation – solution for injection).

Overdose symptoms and methods of treatment
are not known

Interaction with other medicinal products
In a joint application dianabol steroid reduces the effectiveness of levodopa.

Form release Tablets: 10 tablets in a blister; 3 blisters with instruction on use in carton pack. Injection: In 5 ml ampoules of dark glass, 10 vials with the instructions for use in a carton box. how much to inject for weight loss

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